Doctoral Thesis: Graphene-based Biochemical Sensing Array: Materials, System Design and Data Processing
34-401A
Mantian Xue
Thesis abstract: Graphene and other two-dimensional materials have garnered significant attention as potential biochemical and chemical sensors due to their unique physical and electrical properties. However, their use has been limited by significant device-to-device variation resulting from non-uniform synthesis and fabrication processes. To overcome this challenge, we have developed a bioelectronic sensing platform comprising thousands of integrated sensing units, custom-designed high-speed readout electronics, and machine learning-based inference. This platform has demonstrated reconfigurable sensing capability in both the liquid and gas phases, with highly sensitive, reversible, and real-time responses to potassium, sodium, and calcium ions in complexed solutions. Additionally, using a biomimetic “dual-monolayer” construct, we have observed nature-like specific interactions with the CXCL12 ligand and HIV-coat glycoprotein in 100% human serum. Furthermore, the platform is capable of providing highly distinguishable fingerprints of relevant biomarkers in breath. Machine learning models trained on multi-dimensional data collected by the multiplexed sensor array is used to enhance the sensing system’s functionality. In summary, our bioelectronic sensing platform represents an end-to-end, versatile, robust, and high-performing solution for the detection of biochemical species, with potential applications in health monitoring and disease diagnosis.
Details
- Date: Thursday, January 12
- Time: 10:00 am - 11:30 am
- Category: Thesis Defense
- Location: 34-401A
Additional Location Details:
Thesis Supervisor: Professor Tomas Palacios
To attend via Zoom, please contact the doctoral candidate at mxue@mit.edu